101070950 Exploting ex vivo expansion and deep multiomics profiling to bring novel, efficient and safer hematopoietic stem cell gene therapies to clinical application (X-PAND)

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101070950 Exploting ex vivo expansion and deep multiomics profiling to bring novel, efficient and safer hematopoietic stem cell gene therapies to clinical application (X-PAND)

The technological breakthrough of this proposal is to capture HSC in the ex vivo culture, achieved by a combination of innovative expansion conditions, iterative cell sorting and multiomics single cell profiling. Rapid, quantitative and qualitative in vitro HSC assessment predictive of in vivo function may become a sustainable alternative to mouse xenotransplantation experiments.

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Ficha técnica
Financiación
Internacional
Organismo
European Innovation Council and SMEs Executive Agency (EISMEA)
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Fundación Pública Miguel Servet