The Oncoimmunology Research Unit develops gene vaccines for cancer treatment. It analyses their effects in inhibitory cells of the immune system, such as myeloid-derived suppressor cells, which appear in cancer patients and favour tumour progression and metastasis. The team have shown that treatment with a lentiviral vector that expresses an immunostimulating cytokine, a PD-L1 silencing microRNA and a tumour antigen inhibits the function of myeloid-derived suppressor cells and is effective against melanoma.
Navarrabiomed - Centro de investigación biomédica
Complejo Hospitalario de Navarra, edificio de investigación.
Calle Irunlarrea, 3. 31008 Pamplona, Navarra, España.