Oncoimmunology

    Oncoimmunology
    Oncoimmunology
    Gene therapy with lentiviral vectors in cancer treatment

    The Oncoimmunology Research Unit develops gene vaccines for cancer treatment. It analyses their effects in inhibitory cells of the immune system, such as myeloid-derived suppressor cells, which appear in cancer patients and favour tumour progression and metastasis. The team have shown that treatment with a lentiviral vector that expresses an immunostimulating cytokine, a PD-L1 silencing microRNA and a tumour antigen inhibits the function of myeloid-derived suppressor cells and is effective against melanoma.

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    Inmunomodulation

    Navarrabiomed - Centro de investigación biomédica
    Complejo Hospitalario de Navarra, edificio de investigación.
    Calle Irunlarrea, 3. 31008 Pamplona, Navarra, España.