DNA methylation in neurodegenerative diseases such as Alzheimer’s

    This Research Unit’s goal is to describe the DNA methylation pattern and how it affects the development of neurological diseases, especially degenerative dementias like Alzheimer’s disease. The ultimate goal is to find epigenetic biomarkers that could be used for diagnosis, prognosis and treatment. Research in this field covers other neurological disorders such as epilepsy or multiple sclerosis. The Unit is particularly interested in epigenetic modifications in certain rare monogenic disorders associated with neurological disorders like laminopathies.
    The team work in cooperation with other teams from the Navarra Hospital Complex. They study stroke biomarkers along with the Vascular Brain Disease Group, the Neuromuscular Disease and Motor Brain Cell Group and the Multiple Sclerosis Group. Additionally, they aim at describing how environmental factors or targeted activities affect methylation patterns in healthy individuals.

    Lines of research:

    • Identification of epigenetic biomarkers in Alzheimer’s and other neurodegenerative diseases.
    • Neurogenesis mechanisms in Alzheimer’s disease: new therapeutic targets.
    • Epigenetic regulation in laminopathies and other rare diseases.
    • Meditation-induced epigenetic modifications.
    Altuna Azkargorta, Miren
    Complejo Hospitalario de Navarra
    Cabada Giadas, Mª Teresa
    Complejo Hospitalario de Navarra
    Cabello González, Carolina
    Complejo Hospitalario de Navarra
    Echavarri Zalba, Carmen
    Complejo Hospitalario de Navarra
    Erro Aguirre, Elena
    Complejo Hospitalario de Navarra
    Larumbe Ilundain, Rosa
    Complejo Hospitalario de Navarra
    Méndez López, Iván
    Área de Salud de Estella
    Pulido Fontes, Laura
    Complejo Hospitalario de Navarra
    Sánchez Ruiz de Gordoa, Javier
    Complejo Hospitalario de Navarra
    360º Virtual Tour
    Colaboraciones externas
    Mendioroz Iriarte
    Head of the Unit

    Navarrabiomed - Centro de investigación biomédica
    Complejo Hospitalario de Navarra, edificio de investigación.
    Calle Irunlarrea, 3. 31008 Pamplona, Navarra, España.