My tasks are included in the healthcare and research areas, developed in the Hospital Universitario de Navarra and Navarrabiomed, respectively. In the first area I work as the the responsible of the Molecular Pathology Lab at the Department of Pathology (Hospital Universitario de Navarra, Servicio Navarro de Salud) where we analyze the validated biomarkers for diagnosis and prediction of response to oncologic treatments of patients with different types of cancer (breast, lung and colorectal cancer, melanomas,brain tumours,...) from the public hospitals in Navarra (Hospital Complex of Navarra and Hospital Reina Sofía).
We also incorporate the analysis of new biomarkers by different methodologies and the results obtained at this lab are used for immediate clinical decision. In the research area I lead the Molecular Pathology research group in Navarrabiomed, composed by basic researchers, pathologists and clinicians devoted to find new epigenetic alterations with diagnostic, prognostic or predictive value in cancer, mainly breast, colorectal and gynaeocological cancers.
The epigenetic mechanisms we consider are gene hypermethylation, deregulation of miRNA expression, and acetylation of histones, and the technical approach include molecular techniques (global methylation and miRNA expression,pyrosequencing, ...) for the study of nucleic acids (DNA and RNA) and protein, and in vitro techniques, for the development of functional studies (proliferation, invasion, migration,...).
My interest has always been focused on protein biochemistry and proteomics. My thesis work (awarded in 2005) was focused on the identification of biomarkers of non-alcoholic steatohepatitis and hepatocarcinoma using proteomics, obtaining three patents during this period.
During my postdoctoral stage (2006-10), I was involved in a Sixth Framework EU project (FP6) gaining extensive knowledge in proteogenomic strategies to improve the potency and safety of HSV-1 based-oncolytic vectors. As a complement of my scientific training, I completed a Master in Business Management of SMEs (2008). In 2011, I moved to Navarrabiomed Biomedical Research Center (Miguel Servet Foundation, Pamplona, Spain) to establish a research unit focused on the characterization of neurodegenerative proteinopathies dealing with protein expression profiling, multiomics, postranslation modifications, drug repositioning and protein-protein interactions involved in neurological syndromes.
Throughout my scientific career, I have contributed in more than 160 papers, 25 chapter books, and edited three books about cerebrospinal fluid and brain proteomics. I have more than 15 years of experience in leading, mentoring and coaching scientists at all levels of education, being Assistant Professor in several National Biomedical Masters, Associate Professor at Health Sciences Department (UPNA) and directing 8 PhD thesis and multiple master degrees’students.
Graduate in Medicine by the University of Alcalá de Henares (UAH) in Spain; specialist in Clinical Genetics with an European Certificate in Medical Genetics and Genomics (UEMS); and European Doctor PhD in Medicine with extraordinary award distinction. At the healthcare, Consultant Medical Geneticist of the Navarra Public Health Service (SNS-O), and Consultant Clinical Geneticist of the North East and North Cumbria (NHS) Genomic Medicine Center in the United Kingdom between 1996 and 2024.
As a researcher, Leader of the “Oncogenetics and Hereditary Cancer” research groups of the the Health Research Institute of Navarra, IdISNA, and Head of the Genomic Medicine Unit of Navarrabiomed. At the academy, Associate Lecturer of the School of Medicine of the Public University of Navarra in "Personalized Medicine” for Biotechnology, Science, Biomedical Engineering, Data Science, and Medical degrees.
In management and planning in the field of Personalized Medicine, he has been Chief Scientific Officer of the Personalized Medicine Strategy of Navarra Gov; secretary of the Personalized Medicine section of the Spanish Association of Human Genetics (AEGH); advisor to the Spanish Senate on the National Strategy in Genomic Medicine; member of the Executive Committee of the International Consortium for Personalized Medicine ICPerMed; and participant in the mirror groups for the 1 Million Genomes (+1MG) initiative of the European Commission.
World's Top 2% Scientists (Stanford University)
Humberto Bustince is Professor of Computer Science and Artificial Intelligence at the Public University of Navarre and Honorary Professor at the University of Nottingham since 2017. He is the principal researcher of the Group for Artificial Intelligence and Approximate Reasoning. He is the author or co-author of more than 400 papers, according to Web of Science, in prestigious international conferences and journals, with nearly 200 published in first quartile of JCR. In addition, eight of these papers have been among the highly cited papers of the last 10 years according to Web of Science. He collaborates with leading international groups from countries such as the United Kingdom, Belgium, Australia, Germany, Portugal, the Czech Republic, Slovakia, Canada, the USA or Brazil. He is also editor-in-chief of the online magazine Mathware&Soft Computing of the European Association for Fuzzy Logic and Technology (EUSFLAT) and of the journal Axioms. He is a member of the editorial committees of the journals Fuzzy Sets and Systems, Information Fusion, International Journal of Computational Intelligence Systems and Journal of Intelligent & Fuzzy Systems. He is a Fellow of the IEEE Association and a Fellow of the International Fuzzy Systems Association (IFSA). He has served as president of latter association since August 2023. He has been a member of Jakiunde since 2018.
Among his awards, mention should be made of the Cross of Carlos III the Noble granted by the Government of Navarre in 2017; the José García Santesmases National Computer Science Award 2019 and the EUSFLAT Scientific Excellence Award in 2019